Pharmacological reactivity of human epicardial coronary arteries: characterization of relaxation responses to endothelium-derived relaxing factor
نویسندگان
چکیده
منابع مشابه
Endothelium-Derived Relaxing Factor in Resistance Arteries
Vascular endothelial cells importantly contribute to the regulation of vascular smooth muscle tone through the production of a variety of vasoactive substances and by direct electric communication through myoendothelial gap junctions.1,2 Moncada et al3 discovered the first endotheliumderived vasoactive substance, prostacyclin, in the mid 1970s and rapidly identified its structure and chemical c...
متن کاملCyclosporine impairs release of endothelium-derived relaxing factors in epicardial and resistance coronary arteries.
BACKGROUND Cyclosporin A is reported to impair endothelium-mediated vasorelaxation and induce endothelin release in some noncoronary vascular beds. We wished to determine whether acute cyclosporine administration induces endothelial dysfunction in coronary conductance or resistance arteries. METHODS AND RESULTS We examined the effect of intracoronary acetylcholine, N omega-nitro-L-arginine me...
متن کاملEndothelium-derived relaxing factor and coronary vasospasm.
The endothelium releases the powerful vasodilator and antiaggregatory substance, EDRF, both under basal conditions and upon stimulation by a wide variety of agents. Endothelial injury or dysfunction may play an important role in the spasmogenicity of the coronary artery, although other possible alterations related to atherosclerosis should also be considered. Among the possible stimuli, aggrega...
متن کاملEndothelium-Derived Relaxing Factor
The vascular effects of endothelin-1 (ET) in humans were investigated by brachial artery infusions of ET into 25 healthy volunteers. Forearm blood flow increased from a mean±SD value of 2.3± 1.5 to 2.5± 1.5 ml/min/100 ml forearm tissue (n=25, p<0.05) in response to low dose (0.5 ng/min/100 ml forearm tissue) ET infusion and decreased to 1.78±1.3 and 1.1±0.9 ml/min/100 ml forearm tissue (p<0.001...
متن کاملCharacterization and biological significance of endothelium-derived relaxing factor.
The endothelial cell is a highly metabolically active organ which plays a role in metabolizing vasoactive substances and also generates factors which modulate the interactions between platelets and the vessel wall. In 1976, Moncada and colleagues discovered prostacyclin [ 11, one of the most potent of these factors, which inhibits platelet aggregation and induces vasodilatation by stimulating a...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1994
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1994.tb17109.x